Show Book List  | More books by James Watson

Reviews from Amazon
Amazon.com (0375710078) 33 reviews
Amazon.com (0099451840) 33 reviews
Amazon.co.uk (0099451840) 6 reviews
Amazon.co.uk (0375710078) 6 reviews
Amazon.ca (0375710078) 16 reviews
Amazon.ca (0099451840) 16 reviews
A selection of these reviews is given below

Reviews elsewhere on the web:
Journal of Clinical Investigation
Grain.org
Genome News Network
booksamillion.com

James Watson

DNA: The secret of life

James Watson is famous as one of the partnership responsible for the discovery of the structure of DNA, and his book 'The Double Helix' telling the story of that discovery is an international bestseller. In 'DNA: The secret of life' he describes some of the applications that our knowledge of DNA has generated. Its become a vast subject area, and at times I found it difficult to decide how to approach the book - whether each chapter could be read alone or whether they combined into a single thread. However it's well written and maintains the readers interest through its nearly 500 pages. I would recommend it to anyone wanting a readable overview of the current state of genetics.

Many of the areas of modern genetics spawn controversies, and Watson doesn't shy away from giving his point of view on these subjects. This seems to be that we should make the maximum use of the new knowledge which we are gaining, for instance in the development of genetically modified foods and the screening of fetuses for genetic diseases. He also favours the 'nature' side of the 'nature vs nurture' question more than most people. His point of view might seem rather extreme to some people, but it's well argued and deserves to be read by those with opinions on both sides of the arguments.

Amazon.com info
Paperback 464 pages  
ISBN: 0375710078
Salesrank: 566156
Weight:1.75 lbs
Published: 2003 Knopf
Amazon price $18.94
Marketplace:New from $13.97:Used from $2.84
Buy from Amazon.com
Amazon.co.uk info
Paperback 544 pages  
ISBN: 0099451840
Salesrank: 243953
Weight:0.84 lbs
Published: 2004 Arrow Books Ltd
Amazon price £6.95
Marketplace:New from £4.64:Used from £3.00
Buy from Amazon.co.uk
Amazon.ca info
Paperback 464 pages  
ISBN: 0375710078
Salesrank: 80656
Weight:1.75 lbs
Published: 2004 Knopf
Amazon price CDN$ 21.91
Marketplace:New from CDN$ 20.80:Used from CDN$ 15.32
Buy from Amazon.ca






Product Description
Fifty years ago, James D. Watson, then just twentyfour, helped launch the greatest ongoing scientific quest of our time. Now, with unique authority and sweeping vision, he gives us the first full account of the genetic revolution—from Mendel’s garden to the double helix to the sequencing of the human genome and beyond.
Watson’s lively, panoramic narrative begins with the fanciful speculations of the ancients as to why “like begets like” before skipping ahead to 1866, when an Austrian monk named Gregor Mendel first deduced the basic laws of inheritance. But genetics as we recognize it today—with its capacity, both thrilling and sobering, to manipulate the very essence of living things—came into being only with the rise of molecular investigations culminating in the breakthrough discovery of the structure of DNA, for which Watson shared a Nobel prize in 1962. In the DNA molecule’s graceful curves was the key to a whole new science.

Having shown that the secret of life is chemical, modern genetics has set mankind off on a journey unimaginable just a few decades ago. Watson provides the general reader with clear explanations of molecular processes and emerging technologies. He shows us how DNA continues to alter our understanding of human origins, and of our identities as groups and as individuals. And with the insight of one who has remained close to every advance in research since the double helix, he reveals how genetics has unleashed a wealth of possibilities to alter the human condition—from genetically modified foods to genetically modified babies—and transformed itself from a domain of pure research into one of big business as well. It is a sometimes topsy-turvy world full of great minds and great egos, driven by ambitions to improve the human condition as well as to improve investment portfolios, a world vividly captured in these pages.

Facing a future of choices and social and ethical implications of which we dare not remain uninformed, we could have no better guide than James Watson, who leads us with the same bravura storytelling that made The Double Helix one of the most successful books on science ever published. Infused with a scientist’s awe at nature’s marvels and a humanist’s profound sympathies, DNA is destined to become the classic telling of the defining scientific saga of our age.


From the Hardcover edition.
 
An excellent primer on DNA and biotechnology *****
This is an excellent book that takes the reader on an odyssey of the various fields of biotechnology. Needless to say, you need to know what DNA is and how it unfolds its mysteries. The discovery of DNA helix led inevitably to diverse field of biotechnology. DNA affects our life not only through the chromosome but also in myriad ways - useful drugs, genetic finger-printing, agriculture, food, nutrition, disease control, pharmaceuticals and what not. Even where our ancestor was is also traced by DNA. The DNA discoverer himself (known for his witty writings) talks about all these in a lucid way for the lay science readers. I have no background in biology, still I enjoyed this book. I hope others will, as well.
 
Recommended, with the caveat that it is now out of date scientifically ***
This book provides a well rounded approach to DNA from a historical, scientific, and social perspective. It covers the history of the discovery of the double helix structure and then follows with subsequent major breakthroughs, the social fallout from genetically engineered crops, the rise of big-money bio-tech firms and the race to patent gene sequences. I felt that the book dragged on as it delved into the public debates on the role of genetic engineering in society, but to each his own.

My sole reason for writing this review is to alert the reader trying to decide whether to read this book that it is out of date - this book needs a new chapter since it has become clear that the so-called central dogma is not exactly right(i.e., the notion that one gene encodes, via mRNA, one protein) - if you are reading this book as a primer on how DNA works you'll be getting an incomplete and incorrect perspective. For that you'll need to follow the book with some articles that will bring you more up to date: Mattick, John S., The Hidden Genetic Program of Complex Organisms (Scientific American 2004) and Ast, Gil, The Alternative Genome (Scientific American 2005). I'm sure there are others more recent, but that's as far as I've gotten. It also helps to do some searches for DNA on YouTube, since there are some great animations that really help you picture what's going on. So, in sum, the book is OK (maybe a bit tedious at times), but a bit out of date.
 
Really Great Overview *****
This was written so wonderfully. I purchased the audiobook first and just had to have it in print. I highly recommend this to anyone interested in Microbiology. Best non-textbook I've ever read on the subject. We homeschool and this will be required science reading!
 
The Great Contradiction **
What an interesting presentation. On the one hand, we get a ground floor view of the early developments in modeling the DNA molecule. But we also see in grand ironic fashion, that Watson shifts from telling how they borrowed from other people's work to create their grand model, to bellowing the lie that genetic science is neutral, objective and pure, while simultaneously giving tedious detail to the stories of how local interpersonal politics, personality flaws and economics have tremendous influence over the direction and the practice of scientific enterprises, particularly genetic science. Watson basically claims, for example, that we should let scientists and venture capitalists dictate what research will occur, because they are pure of intention, and keep politicians and the public out of it, because their motivations are merely fear and jealousy, (rather than profit and fame?). I cautiously recommend this book as a self-interested look into what can go wrong with the marriage between capitalism and genetic science, and as a book to check out from the local library, for those interested in studying the history, philosophy and economics of genetic scientific discovery.
 
A fun view of a technical subject ****
Andrew Berry's writing made this an interesting book. Watson's colleague, Francis Crick, wrote "An Astonishing Hypothesis" himself and it was a painful thing to read.
I can appreciate the difficulty of setting the scope for a subject that can expand in so many directions, but the focus of several chapters still seem less than completely coherent. The result is that those chapters felt out of place... but on the other hand they were interesting enough in themselves.
Oddly, Watson never tried to support his thesis that DNA is the secret of life, rather than one of the products of life.
On a subject as rapidly changing as the study of DNA, individual years make a difference in the content. The book I bought was a later edition than the one the local library had and it was noticeably updated.
 
Kendra's review *****
I studied biology to bachelors level. This book is very fundamental to the history of genetics. I would say that it doen't cover everything, just the basic history. Neverthless, it is definitely a book for the more academic person. I think parts may go over the heads of the slightly less intellectual.
 
Too little science! **
I was expecting science, but ended up getting corporate propaganda and some "social science" thrown in, such as Watson telling us we should all agree to have our DNA stored on a police database. Things were OK until I reached chapter 5, "DNA, Dollars, and Drugs: Biotechnology", and chapter 6, "Tempest In A Cereal Box". These two chapters are about the commercialisation of genetic science i.e. finding lucrative private-sector jobs for former public workers, biotech scientists. In short, Watson wants profit-driven corporations - not the public - to decide what technologies should come out of certain scientific discoveries, and how these technologies should be applied.

Watson feels particularly aggrieved over the handling of GM food, and how environmentalists and the media have demonised this "useful" technology.

Watson writes, "A meaningful evaluation of GM food should be based on scientific considerations, not political or economic ones."

So what is Watson's scientific evaluation of so-called terminator seeds (seeds that are sterile and will not grow, forcing a farmer to go back to his supplier)? What possible advantage do they confer? Well, none! There is no scientific justification whatsoever for their existence. But, no matter. Watson justifies their existence by claiming that if the majority of farmers buy non-germinating seeds, then this will give corporations the economies of scale they need to invest in, and manufacture, useful "varieties".

In other words, Watson is saying that it is perfectly all right to genetically modify food merely to boost the bottom line of a company, and to encourage farmers and consumers to buy a useless genetic modification in the hope that companies will use this money to come up with something that is actually useful.

Why does this explanation sound suspect? Probably, because the real reason for creating terminator seeds is so that the farmer has to continually buy seed from the company. Other genetic modifications are being used to turn life forms into patented products. The seeds and plants then become the property of corporations - seeds and plants nature created!

So, terminator seeds have absolutely no scientific value. They are not good science, yet Watson tries to defend them on economic grounds, while attacking the public and environmentalists for ignoring the science.

Watson has nothing positive to say about environmentalists, even though many are scientists themselves, who do important work that benefits the public. Watson has now strayed into politics.

Watson also states that "anti-GM" activists sabotaged the prospects of the GM potato, which has built-in resistance to the potato virus. Fries, he claims, now cost more than they should. Given the obesity levels in America, and the concomitant diseases that go with carrying excess weight (heart disease, diabetes, cancer), why do we need cheaper fries? Watson is, yet again, justifying GM food on the supposed economic benefits, rather than on the scientific merits.

Watson overlooks the fact that coffee, for instance, is bought from impoverished "Third World" farmers for a ridiculously low price - sometimes below cost - then large corporations sell that coffee to Westerners at an inflated price. Watson's logic that if food is cheaper to produce, it will be cheaper to end consumers, is flawed.

Watson uses the word "variety" in a completely different sense to its normal use vis-à-vis plants. When we think of varieties of tomatoes, we imagine different shapes, sizes, flavours, and textures. But Watson is using the word to mean the exact same varieties, but with built-in pesticides, herbicide resistance, increased hardiness, sterility, etc. So when Watson talks about genetic manipulation bringing "new varieties" of food onto the market, although it sounds great, it's not what we imagine - it's not, as Watson claims, a modern version of what our ancestors did, who created genuinely new varieties, and gave them to us for free. In fact, we could end up with fewer varieties, as Watson fails to tell us whether just a subset of seeds can be, or will be, genetically modified, while the remaining varieties are eventually - for commercial reasons - discarded.

Watson compares Monsanto's former ambition to dominate the seed business - and therefore our food supply - with Microsoft's dominance of the PC desktop. Watson is wrong to claim that just because a monopoly was prevented, there is nothing to worry about. The notion of turning life itself into a patented technology that is the property of corporations has not gone away, and clearly Watson is doing his best to encourage us to open the door to it. This despite his admission that the patenting of the onco-mouse has limited the use of this important creature in cancer research due to licensing costs.

It is distasteful for Watson to invoke images of dying children to promote GM food, while ignoring the political and economic dimensions to poverty and hunger, which are often far more important.

For instance, what use is GM food to the people of Ghana, who are seeing large amounts of agricultural land being taken away from them for mining use by Western companies? This problem is political and economic, not scientific. There is often plenty of food to feed people - or the potential to produce plenty - but politics and economics gets in the way. To claim GM food will feed the world is a marketing ploy, a way to get us well-fed Westerners to feel so guilty that we fail to engage our critical faculties, and cave in to corporate demands to turn our food into patented technology - technology that cannot be distributed, copied, or otherwise transmitted without the express written permission of the manufacturer.
 
What you must know about genetic engineering *****
Of perhaps a dozon worthwhile books in the world this is one. Yes I come from a computing and engineering background yet this book is fully understandable to me. Its true you need to look back from time to time because unless you are gifted with a good memory you will forget vital experiments. But all the explaination you need is there to understand such things as DNA sequencing and the like. Thank you James Watson for bringing something out for the intelligent public to read and understand.

Yes James does not hasitate to condemn ignorant and dangerous activists who simply understand nothing of what is going on, however having seen some of the computing "errors" that have occured in the field of programming, since the entry of many ignorant and non-thinking participants to the field, I certainly think there is room for more concern than is apparent in this book.

In truth ignorant people are very dangerous whose ever side they may be on, and democracy is no substitute for understanding.

Read this book and understand the very basics of this new miracle.

 
brilliant enthralling read *****
I bought this thinking I might read a chapter or so but found myself unable to put it down. It is really well written and keeps your attention. The colour plates add more interest.

Each chapter deals with a different aspect of DNA. I learnt so much by reading it and have recommended it to everyone I know.

 
A good read! *****
I'm very much enjoying this account, in particular, the background details of the history and of the famous characters involved. I have a little knowledge of DNA history and manipulation, but do not feel that this knowledge would be necessary to enjoy the book!
My only negative comment is that some of the illustrations have been printed slightly too small to really see the details, which is something that I hope the publishers will amend next time.
 
Genetic revolution from Mendel to human genome sequencing *****
Fifty years ago author and scientist James D. Watson helped launch an investigation into the phenomena of human DNA with publication of his now-famous "Double Helix" book: today he gives the first history of the genetic revolution from Mendel to human genome sequencing. Individual chapters consider the rise of molecular science, provide explanations of DNA processes and emerging new sciences surrounding genetics, and provides general-interest readers with a fine blend of science and social issues. This is an important survey and a "must" for school and community library Science and Biology collections.
 
UNTEACHABLETRUTH *****
Oakland schoolchildren can have their DNA tested. They are pleased at the surprising news abour "race." Every human being can be traced to Africa; there never was a master race, a slave race or a foreign race. No more name-calling. No more excuses. The pill may be a little bitter, but science has made humanity better, and equal.

Here is a textboook which every child - on earth - should read. But where do we find teachers?

DNA is fascinating. John Kerry's prominent jaw is a genetic trait.; he's not an alien but a fellow African. An ancestor way back had a mutated gene, that's all. I inherited my dad's bushy eyebrows. If you have freckles - well?

Charlize Theron might have 100% perfect genes, but genes aren't everything. She and her mother speak a German dialect which is not genetic. Watson's book mistakenly implies DNA explains languages. The ability to speak is genetic , but thousands of separate languages evolved by usage; a prominent linguist suggests they all came from a common ancestral language. Out of Africa.

Another mistake in Watson's book is asserting we will never know why humans created "culture." He's not an economist. I would love to explain how foraging tribes got into the art business, but Melinda Gates scoffs at my funding application. Microsoft, mysteriously, owns a chunk of the DNA action.

The fundamental problem with this astounding book is that Watson and other DNA scientists cannot shake off the "Hitler problem" - extermination of genetically "inferior" people. Eugenics was a moronic American movement which led to vast horror - the Holocaust. Warson should be able to get his science off that hook, but doesn't.

Can any teacher use this textbook without preaching eugenics?

 
Shooting quacks *****
James Watson has long been a hero to many, including this humble reviewer. His justified fame is augmented with a laudable forthrightness, a rarity in this era of political correctness and fear of new scientifically grounded knowledge of the nature of the human beast. His honesty in confronting the meaning in the data and willingness to take on the theologians and the pseudo-scientific quacks who infest the departments of theology, anthropology, psychology and sociology of the academies is an inspiration to us all.

DNA is not just a book about genes and DNA. It is about the essential nature of man himself, and the political controversies generated by the new insights. Is is a tale of how this new science is finally vanquishing the old wives' tales, the mantras of the bishops, and the ignorance of the wishful thinkers. Watson is a brilliant exponent of the hard truth over the comfortable conformity.

He was, though, I thought, a little hard on the eugenics movement of the early part of the last century. This is an idea that has never really been vanquished, nor should it be--man will (hopefully) never cease to try to improve himself and his race. These men knew, as we must, that in these matters we are required to proceed in the absence of perfect information about the consequences of our natal policies. In a hundred years our present ignorance will stand revealed, as will that be two hundred years hence. Should we rely on what we know now, or should we only rely on tradition, theologians, and mass-media induced hysteria in the meantime?

On race, Watson is courageous and not afraid to let the data take us where it will. He believes that we have a lot to learn yet on this subject, and is not ready to be pushed around by the dogmatists who are only to willing to tell us how to think. Good for him!

The book is an excellent read, and is very attractive in its layout and generous illustrations. The writing style he uses is exceptionally clear--even conversational at times, navigating the space between talking down to the reader and an academic rant with great skill and sensitivity to his audience. It has a lot for the reader already knowledgeable about molecular biology, as well as, incredibly, the general reader.

 
DNA is a wonderful thing in modern society *****
ABSTRACT
DNA - The Secrets of Life
Authors - James D. Watson with Andrew Berry
Random House, Inc., New York

This book DNA - The secrets of Life goes into depth on more then several subjects on many different levels. The book starts by introducing and walking you through the History or beginning of genetics from Mendel to Hitler. The book is able to answer most all questions/concerns and clarifies any confusion that may be had.

Several chapters in the book or sections, if you will, discuss DNA itself. They start by introducing it as the Double Helix in chapter 2. They go on to further explain throughout the book the coding of DNA and the molecules that are customized in the DNA double helix strand. DNA - The Secrets of Life also writes about the roll DNA plays in Biotechnology and human past and evolution.

The book takes a slight turn at chapter 10 when the topic of DNA comes up in court cases and how it is so useful and highly effective in today's law firms. In the following chapters of the book it presents the idea of Genetic Diseases and how to hunt down the "odd gene out" that is mutated and causes the initial problem. The book continues on by writing of how genetic diseases may be prevented or treated. This chapter presents insight into the cure and the factors and results that play into finding a cure into genetic diseases.

The book ends with a bang of a chapter that asks the question: Who are we? Nature vs. Nurture.

Marc Brien wrote this Abstract

This book brought me to my feet and made me applaud and cheer outloud. It was a delightful book that shared the history/current and possible future discoveres with DNA

 
Thank you, Dr. Watson! *****
This book has achieved a great feat: explaining genetics clearly without dumbing it down.

Tachyos.org  |  Chronon Critical Points  |  Recent Science Book Reviews