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Anthony Smith
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Microbiology Today
Jeff Bond

James Watson

A Passion for DNA

James D. Watson is a controversial figure, with his strong support for gene therapy and genetic modification of plants and animals , and a greater belief in genetic determinism than most geneticists. A Passion for DNA allows the reader to see some of the reasoning behind Watson's beliefs. The book is a collection of essays written by Watson at various times between 1966 and 1999, and we see how he feels that worries about Recombinant DNA were politically stirred up, with no real evidence of danger. He also writes about his views on the ethos of science, on the different approaches to the 'War on Cancer' and on the implication of the Human Genome project.

The book starts off with various autobiographical essays, looking at the background to the discovery of the double helix and what followed it. I felt that these had quite a bit of jargon - more suited for those who are involved in molecular biology. However, these are followed by essays which are more suited for the general reader, with some of them being based on talks which he has given. I felt that the book gives an better insight into Watson as a person than some of the other books he has written - showing in particular his favour of individual choice and his dislike of state control.

Amazon.com info
Paperback 266 pages  
ISBN: 0879696095
Salesrank: 1011156
Weight:1.15 lbs
Published: 2001 Cold Spring Harbor Laboratory Press
Amazon price $16.00
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Amazon.co.uk info
Hardcover 250 pages  
ISBN: 0198604289
Salesrank: 965045
Weight:0.57 lbs
Published: 2001 OUP Oxford
Amazon price £14.00
Marketplace:New from £4.39:Used from £1.23
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Amazon.ca info
Paperback 266 pages  
ISBN: 0879696095
Salesrank: 555541
Weight:1.15 lbs
Published: 2001 Cold Spring Harbor Lab Press
Amazon price CDN$ 16.95
Marketplace:New from CDN$ 14.49:Used from CDN$ 25.24
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Product Description
Jim Watson is one of the world's most famous scientists. A principal architect and visionary of modern biology, a Nobel Prize winner at 34, and best selling author at 40 (The Double Helix), he has been a fearless commentator on the march of DNA science and its impact on society for over twenty years. This sparkling collection was a bestseller in hardcover, and, for the paperback edition, the author has added three newly written essays containing his reflections on the survival value of pursuing happiness, advice for new college graduates, and his thoughts on the completion of a draft of the human genome, a project he initiated over ten years ago.
 
Whoa, this book has been ignored! ****
With the release of "Genes, Girls, and Gamow", this earlier book has suddenly been ignored, overlooked, and forgotten. Nobody, of course, forgets "The Double Helix", and now we have this sensation called "Genes Girls and Gamow". With a bad choice of title and an equally bad choice for a cover---a large close-up picture of a geeky young biologist---making such a mockery and preposterous idea of what appeals to girls in general, I can only salute Rosalind Franklin for her exquisite determination not to be lured by this sly personage. If one wants to examine the life and perspective of the codiscoverer of the structure of the double helix from a more venerable perspective, "A Passion for DNA: Genes Genomes and Society" will earn the reader's respect. From the cover alone of this book, it is almost galling that, by comparison, "Genes Girls and Gamow" gets more brouhaha, hoopla, and hoolabaloo.
 
A Passion for Bible Pounding *****
It is understandable that right to life advocates are desperate to find soap boxes for their religious and political views. However we think it inappropriate to abuse this forum intended for the evaluation of literary works. The expression of political and religious opinions should be reserved for those venues intended for those puposes. Dr. Watson's book is a scientifically insightful and humanistically compassionate work deserving of serious attention.
 
Ethics and DNA ***
James D. Watson's "A Passion For DNA, Genes, Genomes, and Society," Cold Spring Harbor Laboratory Press, 2000, is an interesting historical and non-technical read of 25 essays on a variety of topics dear to his interests. His keen assessment of various individuals and groups that impacted the progress of DNA research can be appreciated by all readers both technical and non-technical.

However, with all respect, I must point out that Dr. Watson departs from his scientific principals when he promotes his positions in the "...ethical, legal and social implications (ELSI) of the new resulting genetic knowledge." [Genes and Politics, p.202]. Especially when he concludes "Thus I do not see genetic diseases in any way as an expression of the complex will of any supernatural authority, but rather as random tragedies that we should do everything in our power to prevent. There is, of course nothing pleasant about terminating the existence of a genetically disabled fetus. But doing so is incomparably more compassionate than allowing an infant to come into the world tragically impaired." [Good Gene, Bad Gene, p. 225]. Jim Watson then takes the position that since "terminating the existence of a genetically disabled fetus" is a "good," only "...the potential mother should have this authority.," never the government, ibid. p. 225.

I see no evidence that Dr. Watson has ever studied "ethics" and/or other philosophical positions that utilize principals and methodologies that "scientifically" examine questions concerning the possibility of the existence of "human souls," the possibility of their immortality, and the nature of their origin, i.e., the possibility of their Divine creation. By restricting himself exclusively to the possibility that all there is to human life is "physical" reality studied in his career as "biological reality," it is inevitable that Dr. Watson's ethical positions concerning the "good" for individuals, families and society be measured and evaluated exclusively in terms of the consequences of physical "evils" and other "random tragedies" generated by the "horrors of genetic disease." Ibid. pp. 224-225.

With no demonstrated knowledge of the existence, or proof of the lack of existence, of human souls, their origin and destinies, Dr. Watson is on very shaky ground "scientifically" to be suggesting this type of solution, i.e., termination of the existence of genetically disabled fetuses, for "victims of unlucky throws of the genetic dice." Ibid. p. 224-225.

For those of us who have established "scientifically" and thus have validly established that the human soul is immaterial and what is more, is immortal, and whose existence as an immortal soul is due to the efficient causality of an uncaused cause, i.e., God, our ethical principals support the "compassionate" caring for the genetically deformed by not only the individuals who they are born to but, also as an obligation of society since this care most often exceeds the resources of any one or two individuals. This position can only be understood by those who either have the knowledge of these truths arrived at by the use of reason and logic (philosophy) or by the tenets of a revealed "faith" (scripture and theology). Yes, Dr. Watson, you believe that the "evolutionary process operating under the Darwinian principles of natural selection" is the only explanation for the existence of "human as well as all other forms of life" Ethical Implications, p. 175, precisely because your scientific method is restricted strictly to the material, physical and hence measurable aspects of existence. But have you examined the arguments (including the starting points and methods) of those of us who do see "evidence for the sanctity (holiness) of life."? You certainly don't present and evidence in your essays of this book that you have, you only present a biased assertion.

I agree with Dr. Watson's principal on page 225, Good Gene, Bad Gene, "Working intelligently and wisely to see that good genes - not bad ones - dominate as many lives as possible is the truly moral way for us to proceed." But this principal does not support "terminating the existence of a genetically disabled fetus" but rather more humanly and Divinely supports the hard work of intelligent research and development of technologies that reduces the possibilities of future "unlucky throws of the genetic dice" happening or occurring before conception or that supports life supportive therapies during fetal growth and after birth resulting in the elimination of or the reduction of genetic disease. As Dr. Watson has said in another place, "Good luck with hard work." I second that!

 
Watson's passion *****
Chris, I've been reading Watson's new book "a passion forDNA". Autobiographical writings on the thought process and earlyDNA players of the 40s 50s and 60s, as well as some more recent musings on recombinant DNA, cancer and the genome.

Very well done! Gives an appreciation for how the obvious can be overlooked, and how difficult it is to break out of old ways of thinking. And the man writes very well... and he shares my politics... hes obviously a genius.

Many insights about who did what, who succeded, who fell short. Good short pieces on Luria, Pauling and Hershey. Points out Caltech's shabby treatment of Pauling on his retirement... they didnt like HIS politics!

I hadn't realized that Alex Rich played an important role in studying the structure of DNA and RNA right at the beginning (the 50s) looking for DNA like structure in RNA, (with Watson at caltech) - they didnt find much and were stumped - though Alex later showed that copolymers of RNA can have double helical structure. And did you know that Francis Crick, in 1968, argued that RNA must have been the original genetic molecule... and that it might act as an enzyme catalyzing its own replication! How right he was. Shades of Ribozyme!

So am I making myself clear... buy this book...

 
Michael Jordan of Biology *****
The man is a genius - Nudge, Nudge say no more. To say the J. Watson has insight is an understatement. Plus he writes in a very understandable way.
 
A hugely enjoyable book ****
As a student studying genetics I found this book fascinating both as it shows the progression of James Watson through his early career to the discovery of the structure of DNA and beyond and also as it gives an insight into how Watson felt upon making these discoveries. The later chapters on his more recent work and on his opinions on more wide ranging topics such as the ethical implications of the Human Genome Project were also very informative.

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